Barbara Bohle Selected Research

Seasonal Allergic Rhinitis (Hay Fever)

1/2022	A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets.
1/2022	Isolation of nanobodies with potential to reduce patients' IgE binding to Bet v 1.
1/2019	Dramatically decreased T cell responses but persistent IgE upon reduced pollen exposure.
1/2019	A novel role for neutrophils in IgE-mediated allergy: Evidence for antigen presentation in late-phase reactions.
10/2017	Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.
8/2017	Tackling Bet v 1 and associated food allergies with a single hybrid protein.
1/2014	The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.
1/2013	Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy.
8/2012	Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background.
2/2011	Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy.

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Barbara Bohle Research Topics

Disease

53	Hypersensitivity (Allergy) 01/2022 - 01/2002
21	Seasonal Allergic Rhinitis (Hay Fever) 01/2022 - 11/2002
16	Food Hypersensitivity (Food Allergy) 01/2022 - 03/2004
5	Inflammation (Inflammations) 01/2022 - 11/2004
3	Atopic Dermatitis (Atopic Eczema) 06/2008 - 05/2004
2	Infections 01/2022 - 01/2021
2	Asthma (Bronchial Asthma) 01/2022 - 05/2018
2	Leukemia 10/2017 - 03/2010
2	Immediate Hypersensitivity 02/2011 - 12/2003
2	Anaphylaxis (Anaphylactic Shock) 01/2011 - 04/2003
2	Skin Diseases (Skin Disease) 07/2005 - 05/2004
1	Autoimmune enteropathy 01/2022
1	Allergic Rhinitis 01/2022
1	Celiac Disease (Celiac Sprue) 01/2022
1	Dust Mite Allergy 03/2021
1	Neoplasms (Cancer) 01/2021
1	Rupture 10/2020
1	Blister (Bulla) 01/2019
1	Pneumonia (Pneumonitis) 05/2018
1	Granuloma 05/2006
1	Eosinophilia 04/2006
1	Hyperhomocysteinemia 12/2003
1	Rheumatoid Arthritis 07/2002

Drug/Important Bio-Agent (IBA)

57	AllergensIBA 01/2022 - 01/2002
24	Immunoglobulin E (IgE)IBA 01/2022 - 04/2003
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2004
13	VaccinesIBA 03/2021 - 06/2004
9	AntibodiesIBA 01/2021 - 07/2005
8	CytokinesIBA 01/2022 - 05/2004
7	Peptides (Polypeptides)IBA 01/2022 - 11/2002
4	EpitopesIBA 01/2022 - 02/2005
4	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2019 - 07/2005
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 05/2018 - 01/2011
3	AntigensIBA 05/2018 - 11/2002
2	Pharmaceutical PreparationsIBA 01/2022 - 04/2003
2	LigandsIBA 01/2022 - 01/2013
2	Immunoglobulin G (IgG)IBA 10/2020 - 03/2011
2	Immunoglobulins (Immunoglobulin)IBA 05/2018 - 11/2004
2	Recombinant ProteinsIBA 01/2018 - 03/2005
2	Interleukin-4 (Interleukin 4)IBA 07/2014 - 07/2009
2	AutoantigensIBA 06/2008 - 07/2002
2	AutoantibodiesIBA 06/2008 - 07/2005
1	TropomyosinIBA 01/2022
1	Glutens (Glutelin)IBA 01/2022
1	Single-Domain AntibodiesIBA 01/2022
1	ProlaminsIBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	Antimicrobial PeptidesIBA 01/2022
1	NADPH Oxidases (NAD(P)H oxidase)IBA 10/2020
1	Blocking AntibodiesIBA 10/2020
1	aluminum sulfate (alum)IBA 10/2020
1	Interleukin-3 (Interleukin 3)IBA 01/2019
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2019
1	FlagellinIBA 01/2018
1	Codon (Codons)IBA 01/2018
1	DisulfidesIBA 10/2017
1	Profilins (Profilin)IBA 10/2017
1	SolutionsIBA 08/2017
1	Interleukin-33IBA 07/2014
1	A-factor (Streptomyces)IBA 01/2014
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2013
1	HLA-DR1 Antigen (HLA DR1 Antigen)IBA 08/2012
1	PyrogensIBA 02/2011
1	EndotoxinsIBA 02/2011
1	GlobulinsIBA 01/2011
1	Histocompatibility Antigens Class IIIBA 03/2010
1	Cysteine (L-Cysteine)FDA Link 03/2010
1	Pru p 3 allergenIBA 07/2009
1	Interleukin-2 (IL2)IBA 07/2009
1	integrin beta7IBA 07/2009
1	Interleukin-10 (Interleukin 10)IBA 07/2009
1	ragweed pollenIBA 06/2009
1	nascent-polypeptide-associated complexIBA 06/2008
1	DNA (Deoxyribonucleic Acid)IBA 08/2007
1	lipid transfer protein (glycolipid transfer protein)IBA 08/2006
1	LatexIBA 08/2006
1	Biological ProductsIBA 03/2005
1	OligonucleotidesIBA 02/2005
1	NucleotidesIBA 02/2005
1	Recombinant Fusion ProteinsIBA 06/2004
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 12/2003
1	HomocysteineIBA 12/2003
1	OligodeoxyribonucleotidesIBA 05/2003
1	propyphenazoneIBA 04/2003
1	pyrazoloneIBA 04/2003
1	Analgesics (Analgesic Drugs)IBA 04/2003
1	CPG-oligonucleotideIBA 11/2002
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 07/2002
1	Filaggrin ProteinsIBA 07/2002

Therapy/Procedure

25	Immunotherapy 01/2022 - 01/2002
5	Therapeutics 01/2022 - 03/2004
1	Oral Administration 01/2017
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2011